The Relationship between the Transforming Growth Factor β1 T29C Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects
المؤلفون المشاركون
Argano, Christiano
Nuzzo, Domenico
Scaglione, Rosario
Di Chiara, Tiziana
Colomba, Daniela
Duro, Giovanni
Fiore, Maria Cristina
Licata, Giuseppe
Corrao, Salvatore
المصدر
International Journal of Hypertension
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The distribution of the T29C TGFβ1 gene polymorphism was analyzed in 198 hypertensives with left ventricular hypertrophy (LVH) and in 235 hypertensives without LVH.
Circulating TGFβ1 levels, procollagen type III levels, microalbuminuria, and left ventricular geometry and function were evaluated in all the hypertensives with LVH subgrouped according to T29C TGFβ1 gene polymorphism.
Circulating TGFβ1 was evaluated by ELISA technique, procollagen type III by a specific radioimmunoassay, microalbuminuria by radioimmunoassay, and left ventricular geometry and function by echocardiography.
All groups were comparable for gender, age, and sex.
Regarding T29C TGFβ1 gene polymorphism, prevalence of TC or CC genotypes was significantly (P<.05) higher in hypertensives with LVH than hypertensives without LVH TC and CC LVH hypertensives were characterized by a higher prevalence of subjects with microalbuminuria (P<.05 TC and CC versus TT), by increased levels of TGFβ1, procollagen type III, urinary albumin excretion, LVM, LVM/h2.7, and lower values of left ventricular ejection fraction (P<.05 TC and CC versus TT).
Our data suggest that T29C TGFβ1 gene polymorphism was associated with clinical characteristics adequate to recognize a subset of LVH hypertensives with a higher severity of hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scaglione, Rosario& Argano, Christiano& Duro, Giovanni& Di Chiara, Tiziana& Nuzzo, Domenico& Colomba, Daniela…[et al.]. 2010. The Relationship between the Transforming Growth Factor β1 T29C Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-487909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scaglione, Rosario…[et al.]. The Relationship between the Transforming Growth Factor β1 T29C Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects. International Journal of Hypertension No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-487909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scaglione, Rosario& Argano, Christiano& Duro, Giovanni& Di Chiara, Tiziana& Nuzzo, Domenico& Colomba, Daniela…[et al.]. The Relationship between the Transforming Growth Factor β1 T29C Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects. International Journal of Hypertension. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-487909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-487909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر