HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population
المؤلفون المشاركون
Xavier Eurico de Alencar, Liciana
Alexandre Antunes de Brito, Carlos
Montenegro, Silvia Maria Lucena
de Mendonça Braga-Neto, Ulisses
Marques, Ernesto Torres de Azevedo
Maria Silva, Ana
Gil, Laura Helena Vega Gonzales
José Moura do Nascimento, Eduardo
Tenório Cordeiro, Marli
da Silva, Maria da Paz Carvalho
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations.
We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil.
An association analysis was performed using Fisher’s association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates.
HLA-B*44 (P=0.047, OR = 2.025, 95% CI = 0.97–4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection.
In addition, HLA-B*07 (P=0.048, OR = 0.501, one-sided 95% CI = 0–0.99) and HLA-DR*13 (P=0.028, OR = 0.511, one-sided 95% CI = 0–0.91) were found to be associated with resistance to secondary dengue infection by DENV-3.
These results suggest that HLA-B*44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B*07 supertype alleles and DR*13 might be involved in cross-dengue serotype immunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xavier Eurico de Alencar, Liciana& de Mendonça Braga-Neto, Ulisses& José Moura do Nascimento, Eduardo& Tenório Cordeiro, Marli& Maria Silva, Ana& Alexandre Antunes de Brito, Carlos…[et al.]. 2013. HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xavier Eurico de Alencar, Liciana…[et al.]. HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-488034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xavier Eurico de Alencar, Liciana& de Mendonça Braga-Neto, Ulisses& José Moura do Nascimento, Eduardo& Tenório Cordeiro, Marli& Maria Silva, Ana& Alexandre Antunes de Brito, Carlos…[et al.]. HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-488034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر