How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer
المؤلفون المشاركون
Soares, Paula
Torres, Joana
Sobrinho-Simões, Manuel
Vinagre, João
Couto, Joana P.
Prazeres, Hugo
Rodrigues, Fernando
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The significance of RET in thyroid cancer comes from solid evidence that, when inherited, an RET activating mutation primes C-cells to transform into medullary carcinomas.
Moreover, environmental exposure to radiation also induces rearranged transforming RET “isoforms” that are found in papillary thyroid cancer.
The RET gene codes for a tyrosine kinase receptor that targets a diverse set of intracellular signaling pathways.
The nature of RET point mutations predicts differences in the mechanisms by which the receptor becomes activated and correlates with different forms of clinical presentation, age of onset, and biological aggressiveness.
A number of RET-targeting Tyrosine Kinase Inhibitors (TKIs) are currently undergoing clinical trials to evaluate their effectiveness in the treatment of thyroid cancer, and it is conceivable that the RET genotype may also influence response to these compounds.
The question that now emerges is whether, in the future, the rational for treatment of refractory thyroid cancer will be based on the management of an abnormal RET signal.
In this paper we address the RET-targeting TKIs and review studies about the signaling properties of distinct RET mutants as a means to predict response and design combinatorial therapies for the soon to be available TKIs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prazeres, Hugo& Torres, Joana& Rodrigues, Fernando& Couto, Joana P.& Vinagre, João& Sobrinho-Simões, Manuel…[et al.]. 2011. How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-489761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prazeres, Hugo…[et al.]. How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer. Journal of Thyroid Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-489761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prazeres, Hugo& Torres, Joana& Rodrigues, Fernando& Couto, Joana P.& Vinagre, João& Sobrinho-Simões, Manuel…[et al.]. How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-489761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-489761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر