Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation
المؤلفون المشاركون
Linhares, Paulo
Vaz, Rui
Figueiredo, Rita
Carvalho, Bruno
Reis, Rui M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
The aim of this study was to determine the frequency of pseudoprogression in a cohort of glioblastoma (GBM) patients following radiotherapy/temozolomide (RT/TMZ) by comparing Macdonald criterial to Response Assessment in Neuro-Oncology (RANO) criteria.
The impact on prognosis and survival analysis was also studied.
Materials and Methods.
All patients receiving RT/TMZ for newly diagnosed GBM from January 2005 to December 2009 were retrospectively evaluated, and demographic, clinical, radiographic, treatment, and survival data were reviewed.
Updated RANO criteria were used for the evaluation of the pre-RT and post-RT MRI and compared to classic Macdonald criteria.
Survival data was evaluated using the Kaplan-Meier and log-rank analysis.
Results and Discussion.
70 patients were available for full radiological response assessment.
Early progression was confirmed in 42 patients (60%) according to Macdonald criteria and 15 patients (21%) according to RANO criteria.
Pseudoprogression was identified in 10 (23.8%) or 2 (13.3%) patients in Macdonald and RANO groups, respectively.
Cumulative survival of pseudoprogression group was higher than that of true progression group and not statistically different from the non-progressive disease group.
Conclusion.
In this cohort, the frequency of pseudoprogression varied between 13% and 24%, being overdiagnosed by older Macdonald criteria, which emphasizes the importance of RANO criteria and new radiological biomarkers for correct response evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Linhares, Paulo& Carvalho, Bruno& Figueiredo, Rita& Reis, Rui M.& Vaz, Rui. 2013. Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation. Journal of Oncology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Linhares, Paulo…[et al.]. Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation. Journal of Oncology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-490838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Linhares, Paulo& Carvalho, Bruno& Figueiredo, Rita& Reis, Rui M.& Vaz, Rui. Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-490838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر