Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation

المؤلفون المشاركون

Linhares, Paulo
Vaz, Rui
Figueiredo, Rita
Carvalho, Bruno
Reis, Rui M.

المصدر

Journal of Oncology

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-08-13

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Introduction.

The aim of this study was to determine the frequency of pseudoprogression in a cohort of glioblastoma (GBM) patients following radiotherapy/temozolomide (RT/TMZ) by comparing Macdonald criterial to Response Assessment in Neuro-Oncology (RANO) criteria.

The impact on prognosis and survival analysis was also studied.

Materials and Methods.

All patients receiving RT/TMZ for newly diagnosed GBM from January 2005 to December 2009 were retrospectively evaluated, and demographic, clinical, radiographic, treatment, and survival data were reviewed.

Updated RANO criteria were used for the evaluation of the pre-RT and post-RT MRI and compared to classic Macdonald criteria.

Survival data was evaluated using the Kaplan-Meier and log-rank analysis.

Results and Discussion.

70 patients were available for full radiological response assessment.

Early progression was confirmed in 42 patients (60%) according to Macdonald criteria and 15 patients (21%) according to RANO criteria.

Pseudoprogression was identified in 10 (23.8%) or 2 (13.3%) patients in Macdonald and RANO groups, respectively.

Cumulative survival of pseudoprogression group was higher than that of true progression group and not statistically different from the non-progressive disease group.

Conclusion.

In this cohort, the frequency of pseudoprogression varied between 13% and 24%, being overdiagnosed by older Macdonald criteria, which emphasizes the importance of RANO criteria and new radiological biomarkers for correct response evaluation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Linhares, Paulo& Carvalho, Bruno& Figueiredo, Rita& Reis, Rui M.& Vaz, Rui. 2013. Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation. Journal of Oncology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490838

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Linhares, Paulo…[et al.]. Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation. Journal of Oncology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-490838

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Linhares, Paulo& Carvalho, Bruno& Figueiredo, Rita& Reis, Rui M.& Vaz, Rui. Early Pseudoprogression following Chemoradiotherapy in Glioblastoma Patients : The Value of RANO Evaluation. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490838

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-490838