Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window
المؤلفون المشاركون
Sotoyama, Hidekazu
Nawa, Hiroyuki
Namba, Hisaaki
Takei, Nobuyuki
Iwakura, Yuriko
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Neuregulin-1 and epidermal growth factor (EGF) are implicated in the pathogenesis of schizophrenia.
To test the developmental hypothesis for schizophrenia, we administered these factors to rodent pups, juveniles, and adults and characterized neurobiological and behavioral consequences.
These factors were also provided from their transgenes or infused into the adult brain.
Here we summarize previous results from these experiments and discuss those from neuropathological aspects.
In the neonatal stage but not the juvenile and adult stages, subcutaneously injected factors penetrated the blood-brain barrier and acted on brain neurons, which later resulted in persistent behavioral and dopaminergic impairments associated with schizophrenia.
Neonatally EGF-treated animals exhibited persistent hyperdopaminergic abnormalities in the nigro-pallido-striatal system while neuregulin-1 treatment resulted in dopaminergic deficits in the corticolimbic dopamine system.
Effects on GABAergic and glutamatergic systems were transient or limited.
Even in the adult stage, intracerebral administration and transgenic expression of these factors produced similar but not identical behavioral impairments, although the effects of intracerebral administration were reversible.
These findings suggest that dopaminergic development is highly vulnerable to circulating ErbB ligands in the pre- and perinatal stages.
Once maldevelopment of the dopaminergic system is established during early development, dopamine-associating behavioral deficits become irreversible and manifest at postpubertal stages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nawa, Hiroyuki& Sotoyama, Hidekazu& Iwakura, Yuriko& Takei, Nobuyuki& Namba, Hisaaki. 2014. Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nawa, Hiroyuki…[et al.]. Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-491489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nawa, Hiroyuki& Sotoyama, Hidekazu& Iwakura, Yuriko& Takei, Nobuyuki& Namba, Hisaaki. Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر