Progress in Using Circulating Tumor Cell Information to Improve Metastatic Breast Cancer Therapy

المؤلفون المشاركون

Schuur, Eric R.
Alemar, Jose

المصدر

Journal of Oncology

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-03-25

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Circulating tumor cells (CTCs) were discovered nearly 150 years ago but have only recently been recognized as a feature of most solid tumors due to their extremely low concentration in the peripheral circulation.

Several technologies have been developed to isolate and analyze CTCs, which can now be routinely accessed for clinical information.

The most mature of these (the CELLSEARCH system) uses immunomagnetic selection of epithelial cell adhesion molecule to isolate CTCs for analysis.

Studies using this system have demonstrated that categorization of patients into high and low CTC groups using a validated decision point is prognostic in patients with metastatic breast, colorectal, or prostate cancer.

Initial attempts to use CTC counts to guide therapeutic decisions appeared to yield positive results and key concepts in clinical application of CTC information, including the CTC cutoff, predictive value in disease subtypes, and comparison to current evaluation methods, have been demonstrated.

Clinical studies of the impact of CTC counts in routine clinical practice are ongoing; however, recent published evidence on the clinical use of CTCs in metastatic breast cancer continues to support these concepts, and experience in the community oncology setting also suggests that CTC enumeration can be useful for therapy management.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Alemar, Jose& Schuur, Eric R.. 2013. Progress in Using Circulating Tumor Cell Information to Improve Metastatic Breast Cancer Therapy. Journal of Oncology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-491751

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Alemar, Jose& Schuur, Eric R.. Progress in Using Circulating Tumor Cell Information to Improve Metastatic Breast Cancer Therapy. Journal of Oncology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-491751

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Alemar, Jose& Schuur, Eric R.. Progress in Using Circulating Tumor Cell Information to Improve Metastatic Breast Cancer Therapy. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-491751

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-491751