Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated
المؤلفون المشاركون
Vallicelli, Carlo
Cavaliere, Davide
Verdecchia, Giorgio Maria
Zuccalà, Valeria
Donato, Giuseppe
Sacco, Rosario
Romano, Roberto
Luposella, Maria
Patruno, Rosa
Sammarco, Giuseppe
Montemurro, Severino
Ranieri, Girolamo
Ammendola, Michele
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-20
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Angiogenesis is a complex process involved in both growth and progression of several human and animal tumours.
Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis.
Mast cells (MCs) can release tryptase following c-Kit receptor (c-KitR) activation.
Method.
In a series of 25 gastric cancer patients with stage T3N2-3M0 (by AJCC for Gastric Cancer 7th Edition), immunohistochemistry and image analysis methods were employed to evaluate in the tumour tissue the correlation between the number of mast cells positive to tryptase (MCPT), c-KitR expressing cells (c-KitR-EC), and microvascular density (MVD).
Results.
Data demonstrated a positive correlation between MCPT, c-KitR-EC, and MVD to each other.
In tumour tissue the mean number of MCPT was 15, the mean number of c-KitR-EC was 20, and the mean number of MVD was 20.
The Pearson test correlating MCPT and MVD, c-KitR-EC and MVD was significantly (r=0.64, P=0.001; r=0.66, P=0.041, resp.).
Conclusion.
In this pilot study, we suggest that MCPT and c-KitR-EC play a role in gastric cancer angiogenesis, so we think that several c-KitR or tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new antiangiogenetic approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ammendola, Michele& Sacco, Rosario& Sammarco, Giuseppe& Donato, Giuseppe& Zuccalà, Valeria& Romano, Roberto…[et al.]. 2013. Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-491798
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ammendola, Michele…[et al.]. Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated. Gastroenterology Research and Practice No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-491798
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ammendola, Michele& Sacco, Rosario& Sammarco, Giuseppe& Donato, Giuseppe& Zuccalà, Valeria& Romano, Roberto…[et al.]. Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-491798
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-491798
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر