The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women

المؤلفون المشاركون

Duława, J.
Więcek, Andrzej
Holecki, M.
Chudek, Jerzy
Titz-Bober, M.

المصدر

International Journal of Endocrinology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-11-24

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأحياء

الملخص EN

Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls.

Serum parathyroid hormone, 25-hydroxyvitamin D3, CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were assessed.

DXA of lumbar spine and femoral neck was performed to determine bone mineral density (BMD).

Plasma iFGF-23 concentration was significantly higher in obese patients (by 42%) and correlated with age and BMD of proximal femur (R=-0.346; R=0.285, resp.) but not with markers of bone turnover.

However, serum phosphorus level in obese subjects was significantly lower.

iFGF-23 concentration correlated significantly with body mass index (R=0.292) and fat content (R=0.259) in all study subjects.

Moreover, a significant correlation between iFGF-23 and iPTH (R=0.254) was found.

No correlation between serum phosphorus or eGFR and plasma iFGF-23 and between eGFR and serum phosphorus was found.

Elevated serum iFGF-23 concentration may partially explain lower phosphorus levels in the obese and seems not to reflect bone turnover.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Holecki, M.& Chudek, Jerzy& Więcek, Andrzej& Titz-Bober, M.& Duława, J.. 2011. The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-492149

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Holecki, M.…[et al.]. The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women. International Journal of Endocrinology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-492149

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Holecki, M.& Chudek, Jerzy& Więcek, Andrzej& Titz-Bober, M.& Duława, J.. The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-492149

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-492149