Energy Homeostasis and Body Weight before and after Cessation of Block and Replacement Therapy in Euthyroid Patients with Graves' Disease

المؤلفون المشاركون

Sauerwein, Hans P.
Kalsbeek, Andries
Klieverik, Lars P.
Ackermans, Mariëtte T.
Fliers, Eric
Wiersinga, Wilmar M.

المصدر

International Journal of Endocrinology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-11-29

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Patients with Graves' hyperthyroidism (GH) treated with a combination of thyrostatic drugs and T4, that is, block and replacement therapy (BRT), often report body weight (BW) gain.

We aimed to determine changes in BW and energy metabolism upon cessation of BRT in these patients, and to identify possible endocrine determinants.

We analysed 22 patients with GH (i) during BRT, and (ii) 12 weeks after BRT cessation.

Patients were euthyroid at both visits.

There were no differences in BW or resting energy expenditure (REE) between visits.

At visit 1, after 13.5 (9.5–48.0) months of BRT, serum free (F)T4 correlated positively with REE (r=0.433, P=0.044) and negatively with body fat % (r=-0.450, P=0.035).

Plasma FT3 and FT3/FT4 ratio showed an increase 12 w after cessation of BRT (20%, P<0.0001 and 16%, P=0.007, resp.).

Moreover, the relative change in FT3/FT4 ratio showed a significant, positive correlation with the relative change in REE between the 2 visits (r=0.465, P=0.029).

In conclusion, serum FT4 determines REE in euthyroid patients with GH treated with BRT.

Twelve weeks after BRT cessation, BW and energy homeostasis are unaltered.

However, as serum FT3/FT4 ratio increases after cessation of BRT, which is a positive determinant of changes in REE, a longer term BW decrease is likely to occur.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Klieverik, Lars P.& Kalsbeek, Andries& Ackermans, Mariëtte T.& Sauerwein, Hans P.& Wiersinga, Wilmar M.& Fliers, Eric. 2011. Energy Homeostasis and Body Weight before and after Cessation of Block and Replacement Therapy in Euthyroid Patients with Graves' Disease. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492799

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Klieverik, Lars P.…[et al.]. Energy Homeostasis and Body Weight before and after Cessation of Block and Replacement Therapy in Euthyroid Patients with Graves' Disease. International Journal of Endocrinology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-492799

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Klieverik, Lars P.& Kalsbeek, Andries& Ackermans, Mariëtte T.& Sauerwein, Hans P.& Wiersinga, Wilmar M.& Fliers, Eric. Energy Homeostasis and Body Weight before and after Cessation of Block and Replacement Therapy in Euthyroid Patients with Graves' Disease. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-492799

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-492799