Nanoencapsulation of Nimodipine in Novel Biocompatible Poly(propylene-co-butylene succinate) Aliphatic Copolyesters for Sustained Release
المؤلفون المشاركون
Bikiaris, Dimitrios N.
Georgarakis, Manolis
Kanaze, Feras I.
Papageorgiou, George Z.
Papadimitriou, Sofia
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-11-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الهندسية و تكنولوجيا المعلومات
الكيمياء
هندسة مدنية
الملخص EN
Biocompatible poly(propylene-co-butylene succinate) (PPBSu) copolyesters, containing up to 50 mol% butylene succinate units, were synthesized by the two-stage melt polycondensation method (esterification and polycondensation).
The copolymers were fully characterized and biocompatibility studies were also performed.
They were proved to be biocompatible and they were used as polymer matrices for the preparation of drug loaded nanoparticles.
Nimodipine was selected as a model hydrophobic poorly water soluble drug.
From the results obtained by dynamic light scattering (DLS) and scanning electron microscopy (SEM), drug loaded copolymer nanoparticles were found to exhibit a spherical shape and their mean diameter appeared in the range of 180–200 nm.
Fourier Transformation-Infrared Spectroscopy (FTIR) spectra indicated that no chemical interaction between the drug and the matrix could be justified, while Wide-Angle X-Ray Diffraction (WAXD) patterns proved a low degree of crystallinity of Nimodipine in the nanoparticles.
The release behavior of the model drug from nanoparticles was also investigated in order to identify modifications and find out any possible correlation between the chemical composition of the polymer matrix and the drug release rates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Papadimitriou, Sofia& Papageorgiou, George Z.& Kanaze, Feras I.& Georgarakis, Manolis& Bikiaris, Dimitrios N.. 2009. Nanoencapsulation of Nimodipine in Novel Biocompatible Poly(propylene-co-butylene succinate) Aliphatic Copolyesters for Sustained Release. Journal of Nanomaterials،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-492886
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Papadimitriou, Sofia…[et al.]. Nanoencapsulation of Nimodipine in Novel Biocompatible Poly(propylene-co-butylene succinate) Aliphatic Copolyesters for Sustained Release. Journal of Nanomaterials No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-492886
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Papadimitriou, Sofia& Papageorgiou, George Z.& Kanaze, Feras I.& Georgarakis, Manolis& Bikiaris, Dimitrios N.. Nanoencapsulation of Nimodipine in Novel Biocompatible Poly(propylene-co-butylene succinate) Aliphatic Copolyesters for Sustained Release. Journal of Nanomaterials. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-492886
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492886
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر