The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration
المؤلفون المشاركون
Richter-Landsberg, Christiane
Vollmer, Grit
Schwarz, Lisa
المصدر
International Journal of Cell Biology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-01-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Filamentous tau-positive protein inclusions in neurons and glia are prominent features of a number of neurodegenerative disorders termed tauopathies.
These inclusions are further characterized by the presence of heat shock proteins (HSPs).
The group of small HSPs, namely, HSP27 and αB-crystallin, interact with the cytoskeleton, bind to nonnative proteins, and prevent their aggregation after stress.
To further investigate their contribution to neurodegenerative diseases, we have analyzed the association of HSP27 with pathological lesions of tauopathies.
Microarray and immunoblot analysis revealed that HSP27 is enhanced at the mRNA and protein levels in affected brains, and that it is associated with astrocytic pathology.
The upregulation of HSP27 in tauopathies with gial pathology implies distinct mechanisms for glial and neuronal cells.
This was sustained by cell culture studies, demonstrating that the small HSPs are specifically and prominently expressed in unstressed astrocytes and not in neurons and in neurons remained at a rather low level even after stress situations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schwarz, Lisa& Vollmer, Grit& Richter-Landsberg, Christiane. 2010. The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. International Journal of Cell Biology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-492993
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schwarz, Lisa…[et al.]. The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. International Journal of Cell Biology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-492993
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schwarz, Lisa& Vollmer, Grit& Richter-Landsberg, Christiane. The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. International Journal of Cell Biology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-492993
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-492993
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر