Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome

المؤلفون المشاركون

Durand, Thierry
Guerranti, Roberto
Galano, Jean-Marie
Hayek, Joussef
Pecorelli, Alessandra
Leoncini, Silvia
Landi, Claudia
Cortelazzo, Alessio
Zollo, Gloria
Bini, Luca
Signorini, Cinzia
Oger, Camille
Ciccoli, Lucia
Montomoli, Barbara
De Felice, Claudio
Giuseppe, Valacchi

المصدر

Mediators of Inflammation

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-12-09

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض

الملخص EN

The mechanism of action of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) is only partially known.

Prior reports suggest a partial rescue of clinical symptoms and oxidative stress (OS) alterations following ω-3 PUFAs supplementation in patients with Rett syndrome (RTT), a devastating neurodevelopmental disorder with transient autistic features, affecting almost exclusively females and mainly caused by sporadic mutations in the gene encoding the methyl CpG binding protein 2 (MeCP2) protein.

Here, we tested the hypothesis that ω-3 PUFAs may modify the plasma proteome profile in typical RTT patients with MECP2 mutations and classic phenotype.

A total of 24 RTT girls at different clinical stages were supplemented with ω-3 PUFAs as fish oil for 12 months and compared to matched healthy controls.

The expression of 16 proteins, mainly related to acute phase response (APR), was changed at the baseline in the untreated patients.

Following ω-3 PUFAs supplementation, the detected APR was partially rescued, with the expression of 10 out of 16 (62%) proteins being normalized.

ω-3 PUFAs have a major impact on the modulation of the APR in RTT, thus providing new insights into the role of inflammation in autistic disorders and paving the way for novel therapeutic strategies.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

De Felice, Claudio& Cortelazzo, Alessio& Signorini, Cinzia& Guerranti, Roberto& Leoncini, Silvia& Pecorelli, Alessandra…[et al.]. 2013. Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493426

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

De Felice, Claudio…[et al.]. Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-493426

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

De Felice, Claudio& Cortelazzo, Alessio& Signorini, Cinzia& Guerranti, Roberto& Leoncini, Silvia& Pecorelli, Alessandra…[et al.]. Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-493426

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-493426