Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response
المؤلفون المشاركون
Wang, Desheng
Gonzalez-Joekes, Jimena
Smith-Bell, Carrie A.
Schreurs, Bernard G.
Bell, Roger
Burhans, Lauren B.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A rabbit model of Alzheimer’s disease based on feeding a cholesterol diet for eight weeks shows sixteen hallmarks of the disease, including learning and memory changes.
Although we have shown 2% cholesterol and copper in water can retard learning, other studies show feeding dietary cholesterol before learning can improve acquisition whereas feeding cholesterol after learning can degrade long-term memory.
We explored this issue by manipulating cholesterol concentration and duration following classical trace conditioning of the rabbit’s nictitating membrane response and assessed conditioned responding after eight weeks on cholesterol.
First, rabbits given trace classical conditioning followed by 0.5%, 1%, or 2% cholesterol for eight weeks showed body weight and serum cholesterol levels that were a function of dietary cholesterol.
Although all concentrations of cholesterol showed some sign of retarding long-term memory, the level of memory retardation was correlated with serum cholesterol levels.
Second, rabbits given trace conditioning followed by different durations of a 2% cholesterol diet combined with different durations of a 0% control diet for 8 weeks showed duration and timing of a 2% cholesterol diet were important in affecting recall.
The data support the idea that dietary cholesterol may retard long-term memory.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schreurs, Bernard G.& Wang, Desheng& Smith-Bell, Carrie A.& Burhans, Lauren B.& Bell, Roger& Gonzalez-Joekes, Jimena. 2012. Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schreurs, Bernard G.…[et al.]. Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-494320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schreurs, Bernard G.& Wang, Desheng& Smith-Bell, Carrie A.& Burhans, Lauren B.& Bell, Roger& Gonzalez-Joekes, Jimena. Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit’s Nictitating Membrane Response. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر