Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
المؤلفون المشاركون
Wang, Liyun
Park, Sung-Soo
Becker, Kevin G.
Maudsley, Stuart
WoodIII, William H.
Stranahan, Alexis M.
Martin, Bronwen
Zhang, Yongqing
Chadwick, Wayne
المصدر
International Journal of Endocrinology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-27
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment.
The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity.
Severe disturbances in energy metabolism, such as those that occur in obesity, are therefore likely to be associated with disruption of hypothalamic transcriptomic plasticity.
In this paper, we investigated the effects of two well-characterized antiaging interventions, caloric restriction and voluntary wheel running, in two distinct physiological paradigms, that is, diabetic (db/db) and nondiabetic wild-type (C57/Bl/6) animals to investigate the contextual sensitivity of hypothalamic transcriptomic responses.
We found that, both quantitatively and qualitatively, caloric restriction and physical exercise were associated with distinct transcriptional signatures that differed significantly between diabetic and non-diabetic mice.
This suggests that challenges to metabolic homeostasis regulate distinct hypothalamic gene sets in diabetic and non-diabetic animals.
A greater understanding of how genetic background contributes to hypothalamic response mechanisms could pave the way for the development of more nuanced therapeutics for the treatment of metabolic disorders that occur in diverse physiological backgrounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stranahan, Alexis M.& Martin, Bronwen& Chadwick, Wayne& Park, Sung-Soo& Wang, Liyun& Becker, Kevin G.…[et al.]. 2012. Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-494361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stranahan, Alexis M.…[et al.]. Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions. International Journal of Endocrinology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-494361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stranahan, Alexis M.& Martin, Bronwen& Chadwick, Wayne& Park, Sung-Soo& Wang, Liyun& Becker, Kevin G.…[et al.]. Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-494361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر