KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats
المؤلفون المشاركون
Kim, Chan-Sik
Lee, Yun Mi
Kim, Young Sook
Kim, Hyojun
Sohn, Eun Jin
Jeong, Il-Ha
Kim, Jin Sook
Jang, Dae Sik
Kim, Junghyun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications, including diabetic nephropathy.
KIOM-79, an 80% ethanolic extract obtained from parched Puerariae Radix, gingered Magnolia Cortex, Glycyrrhiza Radix and Euphorbia Radix, was investigated for its effects on the development of renal disease in Zucker diabetic fatty rats, an animal model of type 2 diabetes.
In vitro inhibitory effect of KIOM-79 on AGEs cross-linking was examined by enzyme-linked immunosorbent assay (ELISA).
KIOM-79 (50 mg/kg/day) was given to Zucker diabetic fatty rats for 13 weeks.
Body and kidney weight, blood glucose, glycated hemoglobin, urinary albumin and creatinine excretions were monitored.
Kidney histopathology, collagen accumulation, fibrinogen and transforming growth factor-beta 1 (TGF-β1) expression were also examined.
KIOM-79 reduced blood glucose, kidney weight, histologic renal damage and albuminuria in Zucker diabetic fatty rats.
KIOM-79 prevented glomerulosclerosis, tubular degeneration, collagen deposition and podocyte apoptosis.
In the renal cortex, TGF-β1, fibronectin mRNA and protein were significantly reduced by KIOM-79 treatment.
KIOM-79 reduces AGEs accumulation in vivo, AGE–protein cross-linking and protein oxidation.
KIOM-79 could be beneficial in preventing the progression of diabetic glomerularsclerosis in type 2 diabetic rats by attenuating AGEs deposition in the glomeruli.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Young Sook& Kim, Junghyun& Kim, Chan-Sik& Sohn, Eun Jin& Lee, Yun Mi& Jeong, Il-Ha…[et al.]. 2011. KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-496738
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Young Sook…[et al.]. KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-496738
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Young Sook& Kim, Junghyun& Kim, Chan-Sik& Sohn, Eun Jin& Lee, Yun Mi& Jeong, Il-Ha…[et al.]. KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-496738
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496738
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر