Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics
المؤلفون المشاركون
Liu, Pu-Zhao
Song, Hai-Yan
Zhao, Yu-Ping
Dong, Yang
Li, Ming
Ding, Yue
Shi, Jian-Rong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the correlation between presbycusis and kidney deficiency as defined by traditional Chinese medicine (TCM) and its material basis from the perspective of metabolism.
Methods.
Pure-tone audiometry was used to test auditory function.
A kidney deficiency symptom scoring table was used to measure the kidney deficiency accumulated scores of the research subjects.
Gas chromatography/mass spectrometry (GC/MS) was used to measure the metabolites in the urine samples from 11 presbycusis patients and 9 elderly people with normal hearing.
Results.
Hearing loss in the elderly was positively correlated with kidney deficiency score in TCM.
There were significant differences in urine metabolite profile between the presbycusis patients and the controls.
A total of 23 differentially expressed metabolites were found.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these metabolites were related to glutathione metabolism, amino acid metabolism, glucose metabolism, the N-methyl-D-aspartic acid (NMDA) receptor pathway, and the γ-aminobutyric acid (GABA) receptor pathway.
Conclusion.
Glutathione metabolism, amino acid metabolism, glucose metabolism, NMDA receptors, and GABA receptors may be related to the pathogenesis of presbycusis and may be the material basis underlying the correlation between presbycusis and kidney deficiency in TCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Yang& Ding, Yue& Liu, Pu-Zhao& Song, Hai-Yan& Zhao, Yu-Ping& Li, Ming…[et al.]. 2013. Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496766
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Yang…[et al.]. Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-496766
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Yang& Ding, Yue& Liu, Pu-Zhao& Song, Hai-Yan& Zhao, Yu-Ping& Li, Ming…[et al.]. Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GCMS Metabolomics. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496766
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496766
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر