Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis

المؤلفون المشاركون

Quignodon, Laure
Desvergne, Bèatrice
Hall, M. G.

المصدر

PPAR Research

العدد

المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2008-11-09

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

peroxisome proliferator-activated receptors (PPARs) are nuclear receptors acting as lipid sensors.

Besides its metabolic activity in peripheral organs, the PPAR beta/delta isotype is highly expressed in the brain and its deletion in mice induces a brain developmental defect.

Nevertheless, exploration of PPARβ action in the central nervous system remains sketchy.

The lipid content alteration observed in PPARβ null brains and the positive action of PPARβ agonists on oligodendrocyte differentiation, a process characterized by lipid accumulation, suggest that PPARβ acts on the fatty acids and/or cholesterol metabolisms in the brain.

PPARβ could also regulate central inflammation and antioxidant mechanisms in the damaged brain.

Even if not fully understood, the neuroprotective effect of PPARβ agonists highlights their potential benefit to treat various acute or chronic neurological disorders.

In this perspective, we need to better understand the basic function of PPARβ in the brain.

This review proposes different leads for future researches.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hall, M. G.& Quignodon, Laure& Desvergne, Bèatrice. 2008. Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-497416

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hall, M. G.…[et al.]. Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-497416

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hall, M. G.& Quignodon, Laure& Desvergne, Bèatrice. Peroxisome Proliferator-Activated Receptor βδ in the Brain : Facts and Hypothesis. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-497416

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-497416