The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Pecháňová, Olga
Ševčík, Rudolf
Vranková, Stanislava
Dovinová, Ima
Barta, Andrej
Parohová, Jana
Kovacsová, Maria
Kondrashov, Alexey
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
We aimed to perform a chemical analysis of both Alibernet red wine and an alcohol-free Alibernet red wine extract (AWE) and to investigate the effects of AWE on nitric oxide and reactive oxygen species production as well as blood pressure development in normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs).
Total antioxidant capacity together with total phenolic and selected mineral content was measured in wine and AWE.
Young 6-week-old male WKY and SHR were treated with AWE (24,2 mg/kg/day) for 3 weeks.
Total NOS and SOD activities, eNOS and SOD1 protein expressions, and superoxide production were determined in the tissues.
Both antioxidant capacity and phenolic content were significantly higher in AWE compared to wine.
The AWE increased NOS activity in the left ventricle, aorta, and kidney of SHR, while it did not change NOS activity in WKY rats.
Similarly, increased SOD activity in the plasma and left ventricle was observed in SHR only.
There were no changes in eNOS and SOD1 expressions.
In conclusion, phenolics and minerals included in AWE may contribute directly to increased NOS and SOD activities of SHR.
Nevertheless, 3 weeks of AWE treatment failed to affect blood pressure of SHR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kondrashov, Alexey& Vranková, Stanislava& Dovinová, Ima& Ševčík, Rudolf& Parohová, Jana& Barta, Andrej…[et al.]. 2012. The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499549
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kondrashov, Alexey…[et al.]. The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-499549
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kondrashov, Alexey& Vranková, Stanislava& Dovinová, Ima& Ševčík, Rudolf& Parohová, Jana& Barta, Andrej…[et al.]. The Effects of New Alibernet Red Wine Extract on Nitric Oxide and Reactive Oxygen Species Production in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-499549
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499549
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر