An Insight into the Interactions between α-Tocopherol and Chitosan in Ultrasound-Prepared Nanoparticles

الملخص EN

The aim of this study was to investigate the interactions between α-tocopherol and chitosan molecules prepared subsequent to preparation of α-tocopherol-loaded chitosan nanoparticles using ultrasonication.

Dynamic light scattering (DLS) and scanning electron microscopy (SEM) analyses showed semispherical particles with an average size of approximately 350 nm.

Also from reconstitution test, α-tocopherol was suggested as stabilizing agent during lyophilization/reconstitution process.

The zeta potentials of chitosan and α-tocopherol nanoparticles were larger than ±30 mV, representing suitable stability.

Data obtained from FTIR showed possibility of chemical interaction between chitosan and α-tocopherol.

Furthermore, the results from FTIR, NMR, and XRD spectroscopy confirmed electrostatic interactions between the two molecules.

Overall, this procedure could be considered as a facile method to prepare α-tocopherol-loaded nanoparticles.