![](/images/graphics-bg.png)
The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia
المؤلفون المشاركون
Régis, Bordet
Marche, Kevin
Rolland, Benjamin
Cottencin, Olivier
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-15
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Oxidative stress has been implicated in neurodevelopmental theories of schizophrenia.
Antioxidant Peroxysome Proliferator-Activated Receptors α (PPARα) agonist fenofibrate has neuroprotective properties and could reverse early preclinical infringements that could trigger the illness.
We have evaluated the neuroprotective interest of fenofibrate in a neurodevelopmental rat model of schizophrenia.
The oxidative lesion induced by Kainic Acid (KA) injection at postnatal day (PND) 7 has previously been reported to disrupt Prepulse Inhibition (PPI) at PND56 but not at PND35.
In 4 groups of 15 male rats each, KN (KA-PND7 + normal postweaning food), KF (KA-PND7 + fenofibrate 0.2% food), ON (saline-PND7 + normal food), and OF (saline + fenofibrate food), PPI was recorded at PND35 and PND56.
Three levels of prepulse were used: 73 dB, 76 dB, and 82 dB for a pulse at 120 dB.
Four PPI scores were analyzed: PPI73, PPI76, PPI82, and mean PPI (PPIm).
Two-way ANOVAs were used to evaluate the effects of both factors (KA + fenofibrate), and, in case of significant results, intergroup Student’s t-tests were performed.
We notably found a significant difference (P<0.05) in PPIm between groups KN and KF at PND56, which supposes that fenofibrate could be worthy of interest for early neuroprotection in schizophrenia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rolland, Benjamin& Marche, Kevin& Cottencin, Olivier& Régis, Bordet. 2012. The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia. Schizophrenia Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502348
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rolland, Benjamin…[et al.]. The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia. Schizophrenia Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-502348
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rolland, Benjamin& Marche, Kevin& Cottencin, Olivier& Régis, Bordet. The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia. Schizophrenia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502348
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-502348
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)