Progesterone Administration Modulates Cortical TLR4NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats
المؤلفون المشاركون
Zhang, Jian
Shi, Xiao-Yong
Zuo, Gang
Wang, Zhong
Chen, Gang
Fang, Qi
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI) after subarachnoid hemorrhage (SAH).
The aim of the current study was to investigate whether progesterone administration modulated TLR4/NF-κB pathway signaling pathway in the brain at the early stage of SAH.
All SAH animals were subjected to injection of 0.3 ml fresh arterial, non-heparinized blood into prechiasmatic cistern in 20 seconds.
Male rats were given 0 or 16 mg/kg injections of progesterone at post-SAH hours 1, 6, and 24.
Brain samples were extracted at 48 h after SAH.
As a result, SAH could induce a strong up-regulation of TLR4, NF-κB, pro-inflammatory cytokines, MCP-1, and ICAM-1 in the cortex.
Administration of progesterone following SAH could down-regulate the cortical levels of these agents related to TLR4/NF-κB signaling pathway.
Post-SAH progesterone treatment significantly ameliorated the EBI, such as the clinical behavior scale, brain edema, and blood-brain barrier (BBB) impairment.
It was concluded that post-SAH progesterone administration may attenuate TLR4/NF-κB signaling pathway in the rat brain following SAH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhong& Zuo, Gang& Shi, Xiao-Yong& Zhang, Jian& Fang, Qi& Chen, Gang. 2011. Progesterone Administration Modulates Cortical TLR4NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-503035
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhong…[et al.]. Progesterone Administration Modulates Cortical TLR4NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats. Mediators of Inflammation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-503035
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhong& Zuo, Gang& Shi, Xiao-Yong& Zhang, Jian& Fang, Qi& Chen, Gang. Progesterone Administration Modulates Cortical TLR4NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-503035
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503035
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر