Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins
المؤلفون المشاركون
Tan, Joanne T. M.
Davies, Michael J.
Moheimani, Fatemeh
Heather, Alison K.
Brown, Bronwyn E.
van Reyk, David M.
المصدر
Experimental Diabetes Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
During atherosclerosis monocyte-derived macrophages accumulate cholesteryl esters from low-density lipoproteins (LDLs) via lectin-like oxidised LDL receptor-1 (LOX-1) and class AI and AII (SR-AI, SR-AII) and class B (SR-BI, CD36) scavenger receptors.
Here we examined the hypothesis that hyperglycaemia may modulate receptor expression and hence lipid accumulation in macrophages.
Human monocytes were matured into macrophages in 30 versus 5 mM glucose and receptor expression and lipid accumulation quantified.
High glucose elevated LOX1 mRNA, but decreased SR-AI, SR-BI, LDLR, and CD36 mRNA.
SR-BI and CD36 protein levels were decreased.
Normo- and hyperglycaemic cells accumulated cholesteryl esters from modified LDL to a greater extent than control LDL, but total and individual cholesteryl ester accumulation was not affected by glucose levels.
It is concluded that, whilst macrophage scavenger receptor mRNA and protein levels can be modulated by high glucose, these are not key factors in lipid accumulation by human macrophages under the conditions examined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moheimani, Fatemeh& Tan, Joanne T. M.& Brown, Bronwyn E.& Heather, Alison K.& van Reyk, David M.& Davies, Michael J.. 2011. Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503291
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moheimani, Fatemeh…[et al.]. Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Experimental Diabetes Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-503291
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moheimani, Fatemeh& Tan, Joanne T. M.& Brown, Bronwyn E.& Heather, Alison K.& van Reyk, David M.& Davies, Michael J.. Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-503291
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-503291
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر