Effectiveness and Safety of Botulinum Toxin Type A in Children with Musculoskeletal Conditions : What Is the Current State of Evidence?
المؤلفون المشاركون
Hamdy, Reggie C.
Dahan-Oliel, Noémi
Kasaai, Bahar
Montpetit, Kathleen
المصدر
International Journal of Pediatrics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-05
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Children with musculoskeletal conditions experience muscle weakness, difficulty walking and limitations in physical activities.
Standard treatment includes physiotherapy, casting, and surgery.
The use of botulinum toxins appears as a promising treatment on its own, but usually as an adjunct to other treatment modalities and as an alternative to surgery.
The objectives were to establish the evidence on the effectiveness, safety and functional outcome of BTX-A in children with musculoskeletal conditions.
A literature search using five electronic databases identified 24 studies that met our inclusion criteria.
Two randomized clinical trials were included; most studies were case studies with small sample sizes and no control group.
Improvements in gait pattern, function, range of motion, reduction of co-contractions, and avoidance of surgical procedures were found following BTX-A injections.
Adverse events were not reported in 10 studies, minor adverse events were reported in 13 children and there were no severe adverse events.
Additional doses appear safe.
BTX-A is a promising treatment adjunct in improving functional outcomes in children with musculoskeletal conditions.
Future studies including larger samples, longer follow-up periods and a comparison group are required to provide evidence on the effectiveness and safety of this drug in children with musculoskeletal conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dahan-Oliel, Noémi& Kasaai, Bahar& Montpetit, Kathleen& Hamdy, Reggie C.. 2012. Effectiveness and Safety of Botulinum Toxin Type A in Children with Musculoskeletal Conditions : What Is the Current State of Evidence?. International Journal of Pediatrics،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-506511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dahan-Oliel, Noémi…[et al.]. Effectiveness and Safety of Botulinum Toxin Type A in Children with Musculoskeletal Conditions : What Is the Current State of Evidence?. International Journal of Pediatrics No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-506511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dahan-Oliel, Noémi& Kasaai, Bahar& Montpetit, Kathleen& Hamdy, Reggie C.. Effectiveness and Safety of Botulinum Toxin Type A in Children with Musculoskeletal Conditions : What Is the Current State of Evidence?. International Journal of Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-506511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر