Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor

المؤلفون المشاركون

Anose, Bynthia M.
Sanders, Michel M.

المصدر

International Journal of Endocrinology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-12-10

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأحياء

الملخص EN

The zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal transitions (EMTs).

ZEB1 (also known as δEF1, zfhx1a, TCF8, and Zfhep) plays a key role in regulating such diverse processes as T-cell development, skeletal patterning, reproduction, and cancer cell metastasis.

However, the factors that regulate its expression and consequently the signaling pathways in which ZEB1 participates are poorly defined.

Because it is induced by estrogen and progesterone and is high in prostate cancer, we investigated whether tcf8, which encodes ZEB1, is regulated by androgen.

Data herein demonstrate that tcf8 is induced by dihydrotestosterone (DHT) in the human PC-3/AR prostate cancer cell line and that this induction is mediated by two androgen response elements (AREs).

These results demonstrate that ZEB1 is an intermediary in androgen signaling pathways.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Anose, Bynthia M.& Sanders, Michel M.. 2011. Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506777

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Anose, Bynthia M.& Sanders, Michel M.. Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor. International Journal of Endocrinology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506777

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Anose, Bynthia M.& Sanders, Michel M.. Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506777

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-506777