A Decade of Experience Using mTor Inhibitors in Liver Transplantation

المؤلفون المشاركون

Kaplan, Maria
Campsen, Jeffrey
Kam, Igal
Mandell, M. Susan
Zimmerman, Michael A.

المصدر

Journal of Transplantation

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-03-15

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Some studies suggest that Sirolimus (SRL) is associated with an increased risk of death in liver transplant recipients compared to treatment with calcineurin inhibitors (CNIs).

We compared patients who received SRL or CNI in the first year after liver transplant.

Our database included 688 patients who received a liver transplant.

The patients were divided into groups.

(1) CNI + MPS (mycophenolate sodium) at time of discharge.

(2) CNI + MPS at time of discharge; SRL was added within the first 6 months and continued through the first year.

(3) CNI + MPS at time of discharge; SRL was added within the first 6 months and discontinued before the first year.

(4) SRL as primary immunosuppression.

(5) SRL as primary immunosuppression and discontinued before the first year.

We used mortality and graft loss as the primary measures of outcome.

We also quantified renal function using the change in glomerular filtration rate (GFR), the presence of biopsy proven acute cellular reject (ACR), and steroid-resistant rejection (SRR).

There were no significant differences in mortality or graft loss.

There was no difference in patient or graft survival.

Patients that received SRL as primary immunosuppression had 50% less rejection compared to controls.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Campsen, Jeffrey& Zimmerman, Michael A.& Mandell, M. Susan& Kaplan, Maria& Kam, Igal. 2011. A Decade of Experience Using mTor Inhibitors in Liver Transplantation. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-507564

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Campsen, Jeffrey…[et al.]. A Decade of Experience Using mTor Inhibitors in Liver Transplantation. Journal of Transplantation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-507564

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Campsen, Jeffrey& Zimmerman, Michael A.& Mandell, M. Susan& Kaplan, Maria& Kam, Igal. A Decade of Experience Using mTor Inhibitors in Liver Transplantation. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-507564

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-507564