Inflammatory Pain and Corticosterone Response in Infant Rats : Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress
المؤلفون المشاركون
Mikhailenko, Viktor A.
Aloisi, Anna Maria
Butkevich, Irina P.
Bagaeva, Tat'yana R.
Otellin, Vladimir A.
Vershinina, Elena A.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Our researches have shown that gestational stress causes exacerbation of inflammatory pain in the offspring; the maternal 5-HT1A agonist buspirone before the stress prevents the adverse effect.
The serotonergic system and hypothalamo-pituitary-adrenal (HPA) axis are closely interrelated.
However, interrelations between inflammatory pain and the HPA axis during the hyporeactive period of the latter have not been studied.
The present research demonstrates that formalin-induced pain causes a gradual and prolonged increase in plasma corticosterone level in 7-day-old male rats; twenty-four hours after injection of formalin, the basal corticosterone level still exceeds the initial basal corticosterone value.
Chronic treatments of rat dams with buspirone before restraint stress during gestation normalize in the offspring pain-like behavior and induce during the acute phase in the formalin test the stronger corticosterone increase as compared to the stress hormonal elevation in animals with other prenatal treatments.
Negative correlation between plasma corticosterone level and the number of flexes+shakes is revealed in buspirone+stress rats.
The new data enhance the idea about relativity of the HPA axis hyporeactive period and suggest that maternal buspirone prior to stress during gestation may enhance an adaptive mechanism of the inflammatory nociceptive system in the infant male offspring through activation of the HPA axis peripheral link.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Butkevich, Irina P.& Mikhailenko, Viktor A.& Bagaeva, Tat'yana R.& Vershinina, Elena A.& Aloisi, Anna Maria& Otellin, Vladimir A.. 2013. Inflammatory Pain and Corticosterone Response in Infant Rats : Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-507743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Butkevich, Irina P.…[et al.]. Inflammatory Pain and Corticosterone Response in Infant Rats : Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-507743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Butkevich, Irina P.& Mikhailenko, Viktor A.& Bagaeva, Tat'yana R.& Vershinina, Elena A.& Aloisi, Anna Maria& Otellin, Vladimir A.. Inflammatory Pain and Corticosterone Response in Infant Rats : Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-507743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر