Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain
المؤلفون المشاركون
Ryu, Jae K.
McGeer, Patrick L.
Schwab, Claudia
Jantaratnotai, Nattinee
McLarnon, James G.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The validity of amyloid-β peptide (Aβ1–42) intrahippocampal injection, as an animal model of Alzheimer's disease (AD), has previously been considered in terms of inflammatory reactivity and neuronal damage.
In this work, we have extended the testing of the animal model to vasculature by comparison of selected properties of microvessels in vivo with those in human AD brain tissue.
The injection of Aβ1–42, relative to control PBS (phosphate buffered saline), increased the mean number of microvessels and diminished the mean length of microvessels in the molecular layer of dentate gyrus.
The animal model showed Aβ1–42, but not PBS, injection was associated with abnormalities in morphology of microvessels which were characterized as looping, fragmented, knob-like, uneven, and constricted.
In particular, numbers of constricted microvessels, defined as vessels with diameters less than 3 μm, were considerably enhanced for Aβ1–42, compared to PBS, injection.
In comparison, human AD brain demonstrated an elevated number of microvessels with a diminished mean length relative to nondemented (ND) brain.
Additionally, microvessel perturbations in AD brain showed a similar pattern of morphological abnormalities to those observed in Aβ1–42-injected rat hippocampus.
Constricted microvessels were a prominent feature of AD brain but were rarely observed in ND tissue.
These results provide the first evidence that a peptide-injection animal model exhibits a commonality in perturbations of microvessels compared with those evident in AD brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jantaratnotai, Nattinee& Ryu, Jae K.& Schwab, Claudia& McGeer, Patrick L.& McLarnon, James G.. 2011. Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-508046
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jantaratnotai, Nattinee…[et al.]. Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-508046
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jantaratnotai, Nattinee& Ryu, Jae K.& Schwab, Claudia& McGeer, Patrick L.& McLarnon, James G.. Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-508046
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508046
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر