CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer Cells

المؤلفون المشاركون

Berk, Richard
Yu, Minghuan
Kosir, Mary Ann

المصدر

Journal of Oncology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-06-22

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Increased expression of lymphangiogenesis factors VEGF-C/D and heparanase has been correlated with the invasion of cancer.

Furthermore, chemokines may modify matrix to facilitate metastasis, and they are associated with VEGF-C and heparanase.

The chemokine CXCL7 binds heparin and the G-protein-linked receptor CXCR2.

We investigated the effect of CXCR2 blockade on the expression of VEGF-C/D, heparanase, and on invasion.

CXCL7 siRNA and a specific antagonist of CXCR2 (SB225002) were used to treat CXCL7 stably transfected MCF10AT cells.

Matrigel invasion assays were performed.

VEGF-C/D expression and secretion were determined by real-time PCR and ELISA assay, and heparanase activity was quantified by ELISA.

SB225002 blocked VEGF-C/D expression and secretion (P<.01).

CXCL7 siRNA knockdown decreased heparanase (P<.01).

Both SB225002 and CXCL7 siRNA reduced the Matrigel invasion (P<.01).

The MAP kinase signaling pathway was not involved.

The CXCL7/CXCR2 axis is important for cell invasion and the expression of VEGF-C/D and heparanase, all linked to invasion.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yu, Minghuan& Berk, Richard& Kosir, Mary Ann. 2010. CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer Cells. Journal of Oncology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-509834

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yu, Minghuan…[et al.]. CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer Cells. Journal of Oncology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-509834

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yu, Minghuan& Berk, Richard& Kosir, Mary Ann. CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer Cells. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-509834

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-509834