Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection

المؤلفون المشاركون

Bitencourt, Claudia da Silva
Pereira, Priscilla Aparecida Tartari
Sadikot, Ruxana T.
Peres-Buzalaf, Camila
Faccioli, Lúcia Helena
Ramos, Simone Gusmão
Secatto, Adriana
Nicolete, Roberto
Trindade, Bruno Caetano

المصدر

Mediators of Inflammation

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-04-22

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض

الملخص EN

Prostaglandins act as mediators of inflammation and, similar to cytokines, function as immune modulators during innate and adaptive immune responses.

Therefore, using a pharmacological inhibitor, celecoxib, we investigated the role of prostaglandins in host defense against Histoplasma capsulatum infection in C57BL/6 mice.

Our results showed that treatment with celecoxib inhibited cyclooxygenase 2, reduced the total fungal burden, and reduced the concentration of PGE2, cytokines, lymphocytes, neutrophils, and mononuclear cells in the bronchoalveolar space and lung parenchyma.

In addition, celecoxib treatment increased the synthesis of nitric oxide, IFN-γ, LTB4, and the phagocytic capacity of alveolar macrophages.

Moreover, celecoxib treatment increased the survival of mice after infection with a lethal inoculum of H.

capsulatum.

These results suggest that prostaglandins alter the host immune response and play an important role in the pathogenesis of histoplasmosis.

Thus, the inhibition of prostaglandins could be a valuable immunomodulatory strategy and antifungal therapy for histoplasmosis treatment.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Pereira, Priscilla Aparecida Tartari& Trindade, Bruno Caetano& Secatto, Adriana& Nicolete, Roberto& Peres-Buzalaf, Camila& Ramos, Simone Gusmão…[et al.]. 2013. Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-510798

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Pereira, Priscilla Aparecida Tartari…[et al.]. Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-510798

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Pereira, Priscilla Aparecida Tartari& Trindade, Bruno Caetano& Secatto, Adriana& Nicolete, Roberto& Peres-Buzalaf, Camila& Ramos, Simone Gusmão…[et al.]. Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-510798

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-510798