Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study
المؤلفون المشاركون
Gearing, Marla
Scott, Tammy M.
Miller, L. Stephen
Hausman, Dorothy B.
Wittwer, Jonas
Vishwanathan, Rohini
Woodard, John L.
Green, Robert C.
Nelson, Peter T.
Davey, Adam
Johnson, Elizabeth J.
Johnson, Mary Ann
Poon, Leonard W.
Schalch, Wolfgang
Chung, Hae-Yun
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Oxidative stress is involved in age-related cognitive decline.
The dietary antioxidants, carotenoids, tocopherols, and vitamin A may play a role in the prevention or delay in cognitive decline.
In this study, sera were obtained from 78 octogenarians and 220 centenarians from the Georgia Centenarian Study.
Brain tissues were obtained from 47 centenarian decedents.
Samples were analyzed for carotenoids, α-tocopherol, and retinol using HPLC.
Analyte concentrations were compared with cognitive tests designed to evaluate global cognition, dementia, depression and cognitive domains (memory, processing speed, attention, and executive functioning).
Serum lutein, zeaxanthin, and β-carotene concentrations were most consistently related to better cognition (P<0.05) in the whole population and in the centenarians.
Only serum lutein was significantly related to better cognition in the octogenarians.
In brain, lutein and β-carotene were related to cognition with lutein being consistently associated with a range of measures.
There were fewer significant relationships for α-tocopherol and a negative relationship between brain retinol concentrations and delayed recognition.
These findings suggest that the status of certain carotenoids in the old may reflect their cognitive function.
The protective effect may not be related to an antioxidant effect given that α-tocopherol was less related to cognition than these carotenoids.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Johnson, Elizabeth J.& Vishwanathan, Rohini& Johnson, Mary Ann& Hausman, Dorothy B.& Davey, Adam& Scott, Tammy M.…[et al.]. 2013. Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. Journal of Aging Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-510892
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Johnson, Elizabeth J.…[et al.]. Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. Journal of Aging Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-510892
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Johnson, Elizabeth J.& Vishwanathan, Rohini& Johnson, Mary Ann& Hausman, Dorothy B.& Davey, Adam& Scott, Tammy M.…[et al.]. Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. Journal of Aging Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-510892
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510892
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر