Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis

المؤلفون المشاركون

Park, Jae Ho
Kim, Myung-Sunny
Sung, Mi Jeong
Davaatseren, Munkhtugs
Hwang, Jin-Taek
Wang, Shuaiyu

المصدر

Mediators of Inflammation

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-05-16

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Poly-γ-glutamic acid (γ-PGA), naturally secreted from various strains of Bacillus, has anti-inflammatory activity.

In inflammatory bowel disease (IBD), inflammation is promoted and sustained by angiogenesis; however, the role played by γ-PGA in this condition is unclear.

Therefore, we evaluated γ-PGA effects on angiogenesis and inflammation in a dextran sulfate sodium- (DSS-) induced mouse colitis model.

Experimental colitis was induced in male C57BL/6 mice by administering 3% DSS.

Disease activity index (DAI), histopathological scores, microvascular density, myeloperoxidase activity, and VEGF-A and VEGFR2 expression were compared among control mice, DSS-treated mice, and mice receiving 3% DSS along with γ-PGA at 50 mg/kg body weight per day or 3% DSS with γ-PGA at 200 mg/kg body weight per day.

We found that γ-PGA significantly attenuated weight loss, DAI, and colon shortening.

γ-PGA also significantly reduced histopathological evidence of injury.

Moreover, γ-PGA significantly attenuated DSS-induced blood vessel densities.

Furthermore, γ-PGA attenuated DSS-induced expression of VEGF-A and its receptor, VEGFR2.

In addition, γ-PGA treatment led to reduced recruitment of leukocytes to the inflamed colon.

Therefore, our results indicate that γ-PGA has potential application in conditions marked by inflammatory-driven angiogenesis and mucosal inflammation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Davaatseren, Munkhtugs& Hwang, Jin-Taek& Park, Jae Ho& Kim, Myung-Sunny& Wang, Shuaiyu& Sung, Mi Jeong. 2013. Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513389

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Davaatseren, Munkhtugs…[et al.]. Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-513389

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Davaatseren, Munkhtugs& Hwang, Jin-Taek& Park, Jae Ho& Kim, Myung-Sunny& Wang, Shuaiyu& Sung, Mi Jeong. Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513389

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-513389