The efficacy of solifenacin added to α-adrenergic antagonists in the treatment of lower urinary tract symptoms in males with benign prostate hyperplasia : (the Iraqi experience)
المؤلفون المشاركون
al-Hamdani, Nibras I.
Daraji, Sad D.
Zaki, Ali W.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 57، العدد 2 (30 يونيو/حزيران 2015)، ص ص. 119-124، 6ص.
الناشر
تاريخ النشر
2015-06-30
دولة النشر
العراق
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
-Background : The response of overactive bladder (OAB) symptoms seen in men with Lower urinary tract symptoms / Benign prostate hyperplasia (LUTS/BPH) raises the possibility that a combination of α-adrenergic blocker therapy with anticholinergic therapy could both reduce the risk of retention or deteriorating bladder function and also add to the treatment of the remaining obstructive symptoms of LUTS / BPH.
Objective : Is to investigate the efficacy and tolerability of 5mg solifenacin in the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia in combination with an alpha-blocker.
Patients and methods : This is a prospective study of 29 patients with benign prostatic hyperplasia already on alpha-blockers, given solifenacin 5mg once daily.
International prostate symptom score (IPSS), patient micturition diaries, quality of life index (QOL), post-void residual urine (PVR) and maximum flow rate (Qmax) and urodynamic findings were recorded before and after three months of therapy.
Adverse events were documented.
Results: At baseline, the total IPSS was 15.3+5.7 that decreased to 10.8 + 5.3 (net change -4.5, P value < 0.03).
Although the mean IPSS for voiding symptoms was not significant, significant change was noted in the storage symptoms (from 8.4 + 2.4 to 5.1+ 2.5 P value <0.001).
The quality of life index was significantly improved for the patients enrolled from 4.4 + 1.4 to 2.8 + 1.3.
The maximum flow rate increased from 11.6 + 5.7 to 14.3 + 6.1 with a net change of + 2.7 ml / sec (P value < 0.01) ml/sec.
Two patients stopped the medication because of side effects.
The side effects included dry mouth (17.24 %) followed by constipation (6.90 %) then headache and blurred vision (3.45 %) for each.
No urine retention developed in any patient.
Conclusions: The use of solifenacin in selected cases in the treatment of LUTS in patients with BPH is highly effective addition to alpha-blockers
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hamdani, Nibras I.& Daraji, Sad D.& Zaki, Ali W.. 2015. The efficacy of solifenacin added to α-adrenergic antagonists in the treatment of lower urinary tract symptoms in males with benign prostate hyperplasia : (the Iraqi experience). Journal of the Faculty of Medicine Baghdad،Vol. 57, no. 2, pp.119-124.
https://search.emarefa.net/detail/BIM-592736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hamdani, Nibras I.…[et al.]. The efficacy of solifenacin added to α-adrenergic antagonists in the treatment of lower urinary tract symptoms in males with benign prostate hyperplasia : (the Iraqi experience). Journal of the Faculty of Medicine Baghdad Vol. 57, no. 2 (2015), pp.119-124.
https://search.emarefa.net/detail/BIM-592736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hamdani, Nibras I.& Daraji, Sad D.& Zaki, Ali W.. The efficacy of solifenacin added to α-adrenergic antagonists in the treatment of lower urinary tract symptoms in males with benign prostate hyperplasia : (the Iraqi experience). Journal of the Faculty of Medicine Baghdad. 2015. Vol. 57, no. 2, pp.119-124.
https://search.emarefa.net/detail/BIM-592736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 123-124
رقم السجل
BIM-592736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر