دراسة نسيجية من المستخلص المائي لتأثير البابونج على الجهاز التنفسي في ذكور الفئران البيضاء

العناوين الأخرى

Histological study of aqueous extract of chamomile effect on respiratory system in male albino mice

مقدم أطروحة جامعية

الصفار، سرى فؤاد عبد الأمير

مشرف أطروحة جامعية

القيسي، كوكب سليم نجم

الجامعة

جامعة بغداد

الكلية

كلية العلوم

القسم الأكاديمي

قسم علوم الحياة

دولة الجامعة

العراق

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2009

الملخص العربي

The chamomile is one of most famous medicinal plants recomended for treatment of asthma and some respiratory system diseases.

This study was designed to study the effects of aqueous extract of chamomilla recutita on histological structure of some organs of respiratory system.

The study included 40 male albino mice Mus musculus, their age ranged from (5-7) weeks.

The mice were divided randomly to 5 groups and oral adminstered with 1 ml everyday for 10 days :- · Group G1: consider as control group and treated with normal saline · Group G2: was treated with aqueous extract of chamomile with concentration of 3 gm /100 ml D.W · Group G3: was treated with aqueous extract of chamomile with concentration of 5 gm /100 ml D.W.

· Group G4: was treated with aqueous extract of chamomile with concentration of 7 gm /100 ml D.W.

· Group G5: was treated with aqueous extract of chamomile with concentration of 10 gm /100 ml D.W.

Summary The results have shown the followings:- ü The Chamomile has sedative and hypotonic property and stimulates sleep in administered mice.

ü The G5 showed significant (p<0.05) increase in acini diameter means and acinar sac in groups G3, G4and G5.

ü The microscopic examination for trachea showed an increase in trachea diameter means suitable with the concentration of aqueous extract.

The administration with aqueous extract of chamomile showed negative effects on tracheal tissue ranged from mild to extreme effects as compared with control group, in G2 group was mild and in G3 group was moderate, while is was extreme effects in group G4 and G5 act as break down of Trachealis muscularis ,and it's lining epithelium showed metaplasia changes represented by transformation of tissue to simple cuboidal ,and exfoliate layers from epithelium to lumen of trachea .it has been found that epithelial tissue had loose their cilia in some regions .

ü The study of lung sections of groups G3, G4 and G5 showed negative effects of chamomile constituents which appear as widening of acini and acinar sacs then overinflation and finally emphysema, beside congestion of acinar walls and it has been distinguish the degeneration of epithelial nuclei and accumulation of exudates in their lumen, these changes stimulate Summary inflammatory response in away of infiltration of fluid containing inflammatory cells.

ü The microscopic examination of respiratory muscles (diaphragm and intercostals) sections of groups G3,G4 and G5 showed degenerative effects on muscular tissue in away of breaking of myofibrils differences in their sizes and degeneration of most of nuclei of muscle fiber and their migration to inside the muscle fiber ,and it has been found that these treatments cause an alteration in myofibril in fibrotic myofibril.

From this study we conclude that low concentration of aqueous extract of chamomile have low side effect on major respiratory organs and could be used in beneficial treatment to contact diseases of respiratory system but without longer

التخصصات الرئيسية

الأحياء
علم الحيوان
النبات

الموضوعات

• الفسيولوجيا
• الآثار الفسيولوجية
• التشريح
• الجهاز التنفسي
• النباتات الطبية
• الطب البيطري
• الفئران
• الاستخدام العلاجي
• البابونج

عدد الصفحات

97

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

العربية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-597128