Glanzmann’s thrombasthenia, correlation by flow, platelet aggregometry and platelet function assay (PFA)‎

الملخص EN

Objective: To evaluate Glanzmann’s Thrombasthenia (GT) as an inherited bleeding disorder, its age and gender distribution.

Design: A Retrospective Study.

Setting: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Method: Patients were tested for Glanzmann’s Thrombasthenia by platelet immunophenotyping from January 2005 to December 2009.

The results of platelet immunophenotyping were compared with PFA and platelet aggregometry.

Result: Thirty-three (77.3%) were type I, 7 (13.6%) were type II and 4 (9.1%) were type III.

GT was mainly found in females and in pediatric age group.

There was a good correlation between flow cytometry study and aggregation study.

Conclusion: GT is a common bleeding disorder in a community where consanguineous marriage is common.