تأثير بعض المركبات البروتينية المعزولة من نبات الشليك (Fragaria Vesca)‎ على بعض المتغيرات الكيموحيوية للفئران المعرضة للكرب التأكسدي التجريبي

الملخص EN

This study was concerned with preparation of cold aqueous extract of Fragaria Vesca.

the proteinous compound (from cold proteinous precipitate) has been isolated and studied by using the gel filtration chromatography technique where the molecular weight of the compound was (7226) Dalton.

The study also concerned with the effect of crud aqueous proteinous and non protienous extracts, protienous precipitate and compound which was isolated from it in serum glucose, total cholesterol (T.C), high density lipoprotein cholesterol (HDL-c) and uric acid in females mice which was exposed to oxidative stress induced by hydrogen peroxide, in addition glutathione (GSH) and malondialdehyed (MDA) levels was determined in liver, heart and kidney tissues for thase mice.

The results of injection intraperitoneal of mice and after one week of a treatment with proteinous compound, crud aqueous precipitate proteine and proteinous precipitate, indicated significant decrease the levels of serum total cholesterol, serum uric acid, and serum glucose when treated with proteinous precipitate and aqueous extracts proteine, whereas the results indicated that significant increase level of high density lipoprotein cholesterol (HDL-C) when treating with (proteinous precipitate, aqueous proteinous, non proteinous (which caused asignificant increase in glucose level)) extracts, the level of glutathione (GSH) and malondialdehyed (MDA) has also been increased for some tissues when treating with the above mentioned extracts.

Finally, it can be concluded that most extracts of (Fragaria Vesca) plant have a decreased effects for total cholesterol and have an increased effect for high density lipoprotein cholesterol (HDL-C) level and as antioxidants.