The role of TNF-α in the pathogenesis of multiple myeloma : a study in Iraqi patients
العناوين الأخرى
دور عامل نخر الورم الفا (TNF-α) في إمراضيه الورم النخاعي المتعدد : دراسة لمرضى عراقيين
المؤلفون المشاركون
Muhsin, Azhar Jasim
Nimah, Sabah Muhammad
Husayn, Talib Abd Allah
Isa, Muhammad Ahmad
المصدر
العدد
المجلد 11، العدد 2(s) (30 يونيو/حزيران 2014)، ص ص. 853-860، 8ص.
الناشر
جامعة بغداد كلية العلوم للبنات
تاريخ النشر
2014-06-30
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص AR
During recent years, there has been an increasing interest in the investigation of the cytokines roles in pathogenesis of cancer, thus the study aimed at evaluating the level of tumor necrosis factor-alpha(TNF-α) in sera of Iraqi multiple myeloma (MM) patients.
Beta 2-microglobulion (β2-m) was assessed to determine if there was any association between this cytokine and the level of β2- m, as the latter is related to the stage of the disease.
In addition, the age and gender were also taken into consideration.
Furthermore, we investigated the relationship between IgG and TNF-α in sera of patients.
49 Iraqi patients (27 males and 22 females).The patients were also divided into two groups: the first group included (17) patients who were recently diagnosed and not received any treatment at the time of collecting samples while the second group included (32) patients who received treatment.
A further group was also investigated which included (12) apparently healthy individuals (9 males and 3 females), who were regarded as a control group.
Serum TNF-α and β2- m were determined using enzyme-linked immunosorbent assay (ELISA).while the concentration of IgG was measured by radial immune diffusion plates The study reached to the following results: TNF-α levels were not significantly elevated in the patients with MM compared to control group (5.98 ± 8.47 SD vs.
4.85 ± 12.1 SD) and no significant differences (P > 0.05) were observed in the mean (6.02 ±8.1SD vs 5.9 ±9.4SD) concentration of TNF-α in patients with MM who received treatment, when compared with those who did not take the treatment .In addition, there are positive significant correlations between TNF-α and β 2 Microglobulin (r = 0.316, P = 0 .027), and no relationship between IgG and TNF-α (r = - 0.032, P = 0.829).Furthermore, the study observed that, there was no correlation between TNF-α on the one hand and factors of age and gender on the other hand.
الملخص EN
During recent years, there has been an increasing interest in the investigation of the cytokines roles in pathogenesis of cancer, thus the study aimed at evaluating the level of tumor necrosis factor-alpha(TNF-α) in sera of Iraqi multiple myeloma (MM) patients.
Beta 2-microglobulion (β2-m) was assessed to determine if there was any association between this cytokine and the level of β2- m, as the latter is related to the stage of the disease.
In addition, the age and gender were also taken into consideration.
Furthermore, we investigated the relationship between IgG and TNF-α in sera of patients.
49 Iraqi patients (27 males and 22 females).The patients were also divided into two groups: the first group included (17) patients who were recently diagnosed and not received any treatment at the time of collecting samples while the second group included (32) patients who received treatment.
A further group was also investigated which included (12) apparently healthy individuals (9 males and 3 females), who were regarded as a control group.
Serum TNF-α and β2- m were determined using enzyme-linked immunosorbent assay (ELISA).while the concentration of IgG was measured by radial immune diffusion plates The study reached to the following results: TNF-α levels were not significantly elevated in the patients with MM compared to control group (5.98 ± 8.47 SD vs.
4.85 ± 12.1 SD) and no significant differences (P > 0.05) were observed in the mean (6.02 ±8.1SD vs 5.9 ±9.4SD) concentration of TNF-α in patients with MM who received treatment, when compared with those who did not take the treatment .In addition, there are positive significant correlations between TNF-α and β 2 Microglobulin (r = 0.316, P = 0 .027), and no relationship between IgG and TNF-α (r = - 0.032, P = 0.829).Furthermore, the study observed that, there was no correlation between TNF-α on the one hand and factors of age and gender on the other hand.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhsin, Azhar Jasim& Husayn, Talib Abd Allah& Nimah, Sabah Muhammad& Isa, Muhammad Ahmad. 2014. The role of TNF-α in the pathogenesis of multiple myeloma : a study in Iraqi patients. Baghdad Science Journal،Vol. 11, no. 2(s), pp.853-860.
https://search.emarefa.net/detail/BIM-644771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhsin, Azhar Jasim…[et al.]. The role of TNF-α in the pathogenesis of multiple myeloma : a study in Iraqi patients. Baghdad Science Journal Vol. 11, no. 2 (2014), pp.853-860.
https://search.emarefa.net/detail/BIM-644771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhsin, Azhar Jasim& Husayn, Talib Abd Allah& Nimah, Sabah Muhammad& Isa, Muhammad Ahmad. The role of TNF-α in the pathogenesis of multiple myeloma : a study in Iraqi patients. Baghdad Science Journal. 2014. Vol. 11, no. 2(s), pp.853-860.
https://search.emarefa.net/detail/BIM-644771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 857-859
رقم السجل
BIM-644771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر