مستويات IL-6 وhs-CRP المصلية في متلازمة المبيض متعدد الكيسات PCOS

الملخص EN

Women with polycystic ovary syndrome (PCOS) have increased risk of insulin resistance prevalence and related disorders.

Insulin resistance is associated with production of inflammatory proteins and cytokines, like IL-6 and CRP.

The objective of this research was to study these inflammatory markers levels in PCOS patients sand determine its relationship with obesity and index of insulin resistance.

53 women with PCOS were divided, according to BMI, into two groups: group 1 (n = 22, BMI > 25) and group 2 (n =31, BMI < 25), 27 healthy women served as control.

IL-6, hs-CRP, FSH, LH, Prolactin, free testosterone, fasting glucose and insulin were measured.

HOMA-IR was calculated.

Il-6, hs-CRP, fasting insulin and HOMA were significantly higher in group 1 than control group.

HOMA and hs-CRP were significantly higher in group 2 than control group.

IL-6 levels were similar in group 2 and control.

Both of hs-CRP and IL-6 has a positive correlation with BMI and HOMA.

As conclusion, PCOS is associated with an increase in serum hs-CRP (inflammatory and cardiovascular risk marker).

IL-6 and hs-CRP were associated with a marker of obesity (BMI) and insulin resistance criteria.