دراسة مستويات الإيوتاكسين في الداء الرئوي الانسدادي المزمن

الملخص EN

Introduction: Eotaxin is a chemokine which characterized by eosinophil chemotactic and activating effects, which takes part in airway inflammation in chronic obstructive pulmonary disease (COPD).

This study aimed to determine eotaxin values, as a biomarker in clinical evaluation of COPD patients, and to compare its levels with IL-8 and CRP levels.

This study included 35 patients with exacerbation of COPD, 30 patients with stable COPD, and 23 healthy controls.

Automated eosinophil count was done, serum Eotaxin and IL-8 were assessed by ELISA, and serum CRP was assessed by immunoturbidimetric test.

Our results showed an increase in the serum levels of Eotaxin, IL-8, CRP, and Eosinophil percentage in exacerbation COPD patients [(479.484±228.003 pg/mL) (p<0.0001); (76.949±19.268 pg/mL) (p<0.0001); (42.165±17.819 mg/L) (p<0.0001); (3.388%±2.002) (p<0.0001) respectively] compared to healthy controls.

Serum levels of Eotaxin, IL-8, CRP and Eosinophil percentage in stable COPD patients increased – but less than their increase in exacerbation COPD patients – [(318.295±142.446 pg/mL) (p<0.0001); (50.854±11.029 pg/mL) (p<0.0001); (15.203±9.462 mg/L) (p<0.0001); (2.01%±1.506) (p>0.05) respectively] compared to healthy controls.

This indicates the important role of eotaxin in the inflammatory process of the disease, and the association between eotaxin concentrations and COPD severity.

Therefore eotaxin could might be used as a biomarker in the clinical evaluation of COPD.