اختلاف المستويات البلازمية لفيتامينات D و B9 و B12 و مستقلباتها لدى أمهات سوريات لأطفال مصابين بعيوب قلبية خلقية، و أمهات لأطفال أصحاء بحسب بعض العوامل المتعلقة بنمط الحياة

الملخص EN

Vitamins B9, B12, D are crucial for epigenetic mechanisms.

And dietary requirement of these vitamins depends on factors related to lifestyle, like diet and residency.

The current research studies the effect of red meat intake, vitamins intake and residency on the serum level of mentioned vitamins and some metabolic related parameters, in mothers of CHD babies in comparison to mothers of healthy babies.

The study included 80 mothers of CHD children of age under than 3 years, and 50 mothers of healthy children of the same age (control group).

Plasma levels of Folate, methyl malonic acid (MMA), homocysteine ( Hcy), cystathionine (CYS), choline (CHOL), betaine (BET), dimethylglycine (DMG), 25-hydroxy vitamin D (25-OHD), S-adenosyl methionine (SAM), S- adenosyl homocysteine (SAH) of patients and control group were compared according to the mentioned life style.

Mothers of healthy children consumed more red meat compared to mothers of patients (p<0.001).

DMG levels were higher in mothers of CHD children that consumed more than 170 g per week of red meat, compared with control mothers of the same level of red meat consumption (p = 0.027).

MMA and HCY levels differed, according to vitamins consumption, only in the control group (p=0.030, p=0.037, respectively), in the same group SAM levels were higher in rural community resident mothers (p=0.033).

Choline levels were lower in mothers of patients living in rural community, compared to control mothers of the same residency (p = 0.039).

SAH and HCY levels were lower in mothers of CHD children living in urban community compared to urban resident mothers of the control group (p=0.025, p=0.020, respectively), SAH levels were lower also in mothers of patients consuming less red meat compared to the same category of mothers of control children (p=0.029).

25-OHD levels differed according to life style factors.

Taken together our results showed that life style factors affect the studied parameters, and therefore the need for dietary vitamin supplement to reduce CHD risk.