دراسة مستويات الـNGAL للتنبؤ بالأذية الكلوية الحادة لدى أفراد سوريين

الملخص EN

The Neutrophil gelatinase associated lipocalin (NGAL) (also known as Lipocalin 2 or Lcn2) is a small molecule protein (25 Kd) and belongs to the family of the Lipocalins that transport small hydrophobic materials.

Studies have shown the benefit of NGAL in distinguishing the acute and chronic renal injury and prediction of acute renal injury after 2-3 hours of its occurrence compared with creatinine which takes 2-3 days to rise.

Serum level of NGAL, creatinine, urea and sugar was measured in 80 patients, divided into group of patients with acute renal failure and patients group with chronic renal failure and patient group with acute renal attack after they had chronic kidney failure, and patients group of which samples were collected after two hours and 3 days from the occurrence of the acute injury.

We found high levels of NGAL in patient groups compared with the controls.

We also found high levels of NGAL in patients whose sample were collected after two hours of the acute injury, while the values of creatinine and urea were within the normal range.

However, the three parameters increased in samples taken after three days.

This study established that levels of serum NGAL increase in acute renal injury, and thus NGAL level can be used as an early biomarkerthat predicts acute renal injury and diagnoses it before the onset of elevation of creatinine and urea levels.