العلاقة بين بعض المتثابتات الشحمية و الأوستيوكالسين لدى مرضى سوريين مصابين بالسكري النمط الثاني

الملخص EN

Diabetes is a chronic disease and metabolic disorder, which causes serious complications, including cardiovascular disease and peripheral arterial disease and strokes Studies have shown that type 2 diabetes, through the occurrence of insulin resistance, affects the serum osteocalcin levels, which in turn leads to progression of complications.

In this study, serum osteocalcin levels were assayed, and the relationship between the osteocalcin concentrations and lipid parameters and fasting blood glucose was determined, in 40 people divided into control group (20 apparently healthy subjects), and patients group (20 patients with Diabetes mellitus type 2).

Enzyme-linked immunosorbent assay (ELISA) technique was used to determine the serum concentrations of osteocalcin.

Enzymatic colorimetric methods were used to determine the concentrations of Fasting blood glucose and lipid parameters (Triglyceride, total Cholesterol and LDL).

Our results showed significantly decreased osteocalcin levels (p=0.0001) in patients with diabetic group, compared with the control group (mean±SD: 19.006±1.710 ng/ml; 29.400±5.546 ng/ml, respectively).

We also found significant reverse correlation between osteocalcin levels and fasting blood glucose, total cholesterol and triglycerides (p=0.0001, r=-0.742; p=0.002, r=-0.605; p=0.005, r=-0.575, respectively).

While the correlation between osteocalcin with LDL was reverse, but not statistically significant (r=-0.370, p=0.09).

As a conclusion, Low serum osteocalcin levels are significantly associated with type 2 diabetes