تعيين قيم Smac DIABLO المصلية لدى مرضى سرطان بروستاتة سوريين

الملخص EN

Apoptosis and apoptotic proteins play a significant role in the maintenance of the normal cellular number in body's tissues and prevent cancer formation in these tissues.

Recently, researchers discovered Smac/DIABLO which is a mitochondrial protein releases from mitochondria to the cytosol during the activation of apoptosis and interacts with Inhibitor of Apoptosis Proteins (IAPs) leading to the inhibition of the capase-binding activity of IAPs.

Recently, many research studies have supported a major role for this protein in cancer diagnosis in addition to the other tests.

So, the aim of the study was to determine the importance of measuring serum levels of Smac/DIABLO in cancer diagnosis Serum levels of Smac/DIABLO were measured in 20 patients with Prostate cancer and 21 apparently healthy subjects (control cases), using enzyme-linked immunosorbent Assay (ELISA).

Our study showed that serum levels of Smac/DIABLO were significantly decreased (p<0.001) in patients with prostate cancer compared to the control group, and also we found a reverse correlation between the serum levels of Smac/DIABLO in patients group and the serum levels of PSA in the same group.

Our findings suggest that measuring the levels of Smac/DIABLO in the serum may be considered, in addition to the other tests, as a prognostic and diagnostic parameter in patients with prostate cancer