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Fertility after treatment of pediatric Hodgkin’s lymphoma [HL]
المؤلف
المصدر
Arab Journal of Nuclear Sciences and Applications
العدد
المجلد 46، العدد 1 (31 يناير/كانون الثاني 2013)، ص ص. 192-204، 13ص.
الناشر
الجمعية المصرية للعلوم النووية و تطبيقاتها
تاريخ النشر
2013-01-31
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
To identify the long-term effect of chemo-radiotherapy on fertility in Hodgkin’s disease (HD) patients regularly attending the pediatric oncology clinic of NCI, 42 long-term survivors (LTS) (33 males & 9 females) were studied, together with 26 newly-diagnosed (ND) HD patients (15 males & 11 females) and 28 healthy controls.
During 3 years period, all patients subjected to through clinical history/ examination.
Files of LTS were revised for date of diagnoses, original site(s), stage, histopathological subtypes and dose/ duration of therapy.
Clinical examination was done with laying stress on visceromegaly and the presence of lymphadenopathy.
Lab investigations included CBC, ESR, bone marrow biopsy and fertility hormones.
Radiodiagnostic studies (plain X-ray, abdominal sonography, and chest/ abdominal/ pelvic CT scans) were done whenever indicated.
In LTS the mean age was 14.9±3.4 yrs.
(median 15.5 yrs) versus 9.5±3.7 yrs .
(median 8.5 yrs) in ND patients.
In LTS, treatment modalities included radiotherapy [RT] alone (2.4%), chemotherapy [CTH] alone [MOPP, ABVD, OPPA, and COPP] (26.2%) or combination chemoradiotherapy (71.4%).
The mean follow-up time was 7.47±2.19 yrs.
(median 6.75 & 6.75 yrs .).
Increased incidence of high luteinizing hormone (LH)& follicle -stimulating hormone (FSH) and testosterone levels was found in patients who received therapy for one year versus those who received longer period, with no statistically significant difference.
However, the mean values of pre-pubertal male LH and post- pubertal male LH& FSH were statistically significant difference among the three groups.
Azoospermia was seen in 10/11 of LTS, with low testosterone in 2 only.
Finally, the study documented that there is Azoospermia with affection of fertility hormones (in males)in LTS-HD patients.
Recommendations regarding the comprehensive follow-up of therapy for HD were discussed.
Endocrine consultation is needed for Survivors with concerns regarding fertility.
Intervention strategies and new evidence-based surveillance of the long -term effects like screening for early detection of late effects, and chemoprevention are needed for dealing with HD, especially in children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abaza, Aya. 2013. Fertility after treatment of pediatric Hodgkin’s lymphoma [HL]. Arab Journal of Nuclear Sciences and Applications،Vol. 46, no. 1, pp.192-204.
https://search.emarefa.net/detail/BIM-724075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abaza, Aya. Fertility after treatment of pediatric Hodgkin’s lymphoma [HL]. Arab Journal of Nuclear Sciences and Applications Vol. 46, no. 1 (Jan. 2013), pp.192-204.
https://search.emarefa.net/detail/BIM-724075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abaza, Aya. Fertility after treatment of pediatric Hodgkin’s lymphoma [HL]. Arab Journal of Nuclear Sciences and Applications. 2013. Vol. 46, no. 1, pp.192-204.
https://search.emarefa.net/detail/BIM-724075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 202-204
رقم السجل
BIM-724075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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