الأثر التراكمي لجرعات متزايدة من السيميتيدين في إنتاج النطاف في ذكور الفأر

الملخص EN

Increasing doses of cimetidine (150mg/kg, 300mg/kg, 450mg/kg, 600mg/kg) were tested on Swiss strain mouse by intramuscular injection.

The accumulative effect of this drug on spermatogonia was studied within a month, and by intervals (10, 20, 30 days respectively).

The reproductive potency was evaluated by total sperm count of the testis and it’s epididymis, for understanding the intrinsic relation between this drug used as a therapy for gastric ulcer, and the probable infertility occurred during the period of exposure.

The results indicate that the cimetidine, a histamine H2 receptor antagonist (H2 blocker) is a negative factor for sperm production in a dose and period related manner.

In the dose (150 mg/kg), the total sperm count decreased form (15.4 × 106 sperms) in the control to about two thirds (9.6 × 106 sperms) after 30 days of the accumulative injection.

But in the dose (300 mg/kg), the sperm count decrease to less than half (6.16 × 106 sperms) after the same period, whereas in the dose (450 mg/kg), it decreased to about one third (5.08 × 106 sperms).

Finally, the dose (600 mg/kg) led to oligospermia (0.8 × 106 sperms instead of 15.4 × 106 sperms in the control).

It was concluded that the cimetidine inhibits the reproductive potency during spermatogensis, and causes cytotoxicity in high doses, and after a long period of treatment.