تأثير مستخلص الحبة السوداء في فعالية الغدة الدرقية في ذكور الجرذان

الملخص EN

This study carried out to determine the effects of Nigella sativa extract in the function and structure of thyroid gland in male rats .

Twenty male rats were distributed randomly to four groups .First group administrated orally with distelled water and considerd as a control group , while the other groups administrated extract of Nigella sativa at dose ( 25, 50 , 100 ) mg / kg body weight repectively Animals were anesthized and the samples of blood were collected for determine leveles of T3 , T4 and TSH .

Thyroid gland were removed for preparation the histological sections .

Results of this study demonstrated that there were significant increase in weight of thyroid gland in second and third groups compured with a control groups .

Also there was high increase in T3 level second and third groups .

compared with control and group , while there was non significant difference in T4 level in all groups compared with a control group .

Results showed there was significant decrease in TSH level .

Histolosical study showed significant decrease in the height of epithelial cells in second and third group compared with acontrol group, while there was significant increase in the diameter of follicle and the colloid in the second and third group compared with control group.