تأثير المستخلص المائي لمغلي نبات الشيح على مستوى السكر في دم الأرانب الطبيعية و المصابة بفرط كلوكوز الدم و داء السكر التجريبي

الملخص EN

The present study was aimed to evaluate the activity of the santonica decoction on the the fasting blood glucose level in an normal , induced hyperglycemic & experimented diabetic rabbits .

In the 1st.

experiment we were used 15 normoglycemic rabbits , divided into 3 groups : one is control ( given distal water 10 ml / kg of body weight ) & others two were given 100 & 200 mg / Kg body weight of santonica decoction orally for 7 days .

The result in this experiment was revealed significant decrease ( P < 0.01 ) in fasting blood glucose level , however the reduction was within normal limits .In the 2nd.

experiment we used induced 15 hyperglycemic rabbits , divided into 3 groups as occurred in first experiment .

They were fasted for 18 hours & then injected intraperitonially with 4 mg/Kg body weight of 50 % glucose solution .

The blood glucose level were determined after 1, 2 & 4 hours following glucose loading & oral administration of plant extract .

The result was revealed highly significant decrease( P < 0.01 % ) in blood glucose level .

The effect was more pronounced in 200 mg of plant extract compared with 100 mg according with time .In third experiment the effect of santonica decoction on the fasting blood glucose levels were studied in alloxan induced diabetic rabbits , using 15 animals were divided into 3 groups as occurred in 1st.

& 2nd.

experiments of this study .

The fasting blood glucose level was determined after 1 , 3 , 6 & 12 hours following oral administration of plant extract .

The result was revealed highly significant decrease ( P < 0.01 ) in fasting blood glucose level of two groups with 100 mg & 200 mg / Kg body weight according with time .

The results of this study suggest that the aqueous extract of the santonica decoction possesses hypoglycemic effect & its hypoglycemic action could be attributed to the presence of glycosidic & saponin components in this plant .

The water extract might be producing its hypoglycaemic effect by an extra-pancreatic action e.g.

possibly by stimulating glucose utilisation in peripheral tissues.

Although, it remains possible that the water extract may decrease the secretion of the counter-regulatory hormones (glucagon, cortisol and growth hormones) or reduce absorption of glucose from gut