Attenuation of γ-rays hazards on mitochondrial level by cranberry extract in rats

الملخص EN

Current study deals with attenuation of gamma-irradiation induced damages in rats using Cranberry.

Rats weighting (100-120g) were subjected to 8 Gy fractionated doses of gamma rays (2 Gy every other day up to 8 Gy).

Cranberry extract 100 mg/kg body weight was daily administrated before and within radiation exposure period form14 days.

All parameters were investigated at 1st and 14th days post last radiation exposure dose.

Because of antioxidants and anti-inflammatory activity of Cranberry, the investigated parameters; lipid peroxidation and GSH contents, SOD, CAT & GSH-Px activities as well as MMPs (2&9) were detected.

The results revealed that administration of Cranberry extract to irradiated rats significantly ameliorates the changes induced in antioxidant system and TBARs; lipid peroxidation index.

MMP2&9 revealed significant inflammatory responses to gamma-rays increased activity area, while in case of Cranberry treated animals post radiation showed demented MMP2&9 activity areas.

TBARS; lipid peroxidation index were significantly decreased when compared with their equivalent values in irradiated rats.

In conclusion, the administration of Cranberry extract to irradiated rats might provide substantial protection against oxidative damages due to its free radical scavenging and antioxidant properties.

It could be suggested that, Cranberry extract may have a potential benefits in radiotherapy.