دراسة النمط الوراثي للجين CYP2D6 للنساء المصابات بسرطان الثدي اللاتي يتناولن عقار التاموكسيفين

الملخص EN

Tamoxifen has a key role in the management of women with hormone receptor (HR) positive breast cancer.

Tamoxifen is a pro-drug that is metabolised to its active metabolites by the cytochrome P450 (CYP) enzymes including CYP2D6, CYP3A, CYP2B6, and CYP2C19.

The CYP genes are polymorphic resulting in variable enzyme activity.

This study involved 100 women with breast cancer and undergoing treatment (tamoxifen), and 30 healthy women apparently.

Study the genotype of the gene CYP2D6 * 4 also showed that most of the samples did not digest was due to the lack of the presence of this allele The samples digested was mostly homozygous (qq) increased slightly to 45%, which is accountable for the production of the enzyme metabolic weak effectiveness of Metabolic Drug tamoxifen (OR = 1) it was also noted there was not significant differences between the control group and the group of patients.