How does stress affect human being : a molecular dynamic simulation study on cortisol and its glucocorticoid receptor
المؤلفون المشاركون
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 3 (31 مارس/آذار 2017)، ص ص. 488-494، 7ص.
الناشر
تاريخ النشر
2017-03-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Stress can be either positive or negative to human beings.
Under stressful conditions, the mental and physical conditions of human can be affected.
There exists certain relation between stress and illness.
The cortisol and other glucocorticoids bind to the same receptor, which is called glucocorticoid receptor.
Some evidences indicated that cortisol molecule binding to its glucocorticoid receptor was necessary for the stress response.
Up to now, the structure–function relationships between cortisol molecule and its glucocorticoid receptor have not been deliberated from the atomic-level.
In order to get a detailed understanding of the structure–function relationships between the cortisol molecule and glucocorticoids receptor, we have carried out molecular dynamic (MD) simulations on glucocorticoid receptor (Apo system) and cortisol with its glucocorticoid receptor complex (HCY system).
On the basis of molecular dynamic simulations, a couple of key residues were identified, which were crucial for the binding of cortisol molecule.
The results of binding free energy calculations are in good agreement with the experiment data.
Our research gives clear insights from atomic-level into the structural–functional aspects of cortisol molecule and its glucocorticoid receptor, and also provides valuable information for the design of drug which can treat stress related illnesses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Dan& Tian, Geng. 2017. How does stress affect human being : a molecular dynamic simulation study on cortisol and its glucocorticoid receptor. Saudi Journal of Biological Sciences،Vol. 24, no. 3, pp.488-494.
https://search.emarefa.net/detail/BIM-761746
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Dan& Tian, Geng. How does stress affect human being : a molecular dynamic simulation study on cortisol and its glucocorticoid receptor. Saudi Journal of Biological Sciences Vol. 24, no. 3 (Mar. 2017), pp.488-494.
https://search.emarefa.net/detail/BIM-761746
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Dan& Tian, Geng. How does stress affect human being : a molecular dynamic simulation study on cortisol and its glucocorticoid receptor. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 3, pp.488-494.
https://search.emarefa.net/detail/BIM-761746
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 494
رقم السجل
BIM-761746
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر