Superiority of peginterferon α-2a and ribavirin combination over peginterferon α-2a monotherapy in the management of hemodialysis patients with chronic hepatitis C virus infection
المؤلفون المشاركون
al-Aulaqi, Nasir
al-Ghamidi, Aminah
Zagnun, Abbas
Bin Sadiq, Bakr
al-Ghamidi, Said Muhammad
al-Amudi, Abd Allah
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 28، العدد 4 (31 أغسطس/آب 2017)، ص ص. 799-805، 7ص.
الناشر
تاريخ النشر
2017-08-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
- الفيروسات
- المرضى
- المواد المضادة للفيروسات
- غسيل الكلى
- السعودية
- الاستخدام العلاجي
- التهاب الكبد ج
- التهاب الكبد سي
الملخص EN
Hepatitis C virus (HCV) is a common infection affecting 15% of hemodialysis population in Saudi Arabia resulting in delay in transplantation and long-term complications.
The use of peginterferon resulted in sustained virologic response (SVR) in 40%–85% of patients, especially if combined with ribavirin.
The treatment is hampered by the high dropout due to anemia and requirement of blood transfusion resulting from this therapy.
Some studies have shown that the addition of increasing dose of erythropoiesis-stimulating agents (ESA) and reduced dose of ribavirin results in reduced dropout rate with high SVR.
We conducted an openlabel prospective study using either peginterferon α-2a alone (Group I, 32 patients) or peginterferon α-2a plus adjusted dose ribavirin (Group II, 26 patients).
A total of seven patients dropped from the study (2 in Group I and 5 in Group II).
Analysis was done only on patients who completed the study (thirty patients in Group I and 21 in Group II).
There was no significant difference in the demographic data, HCV genotype, liver biopsy grade and stage, and laboratory tests between the two groups.
Patients received ESA to combat expected anemia.
Group II had a better early virologic response than Group I [17 out of 21 (80%) and 14 out of 30 (47%) respectively, P = 0.014] and better SVR [18 out of 21 (85%) and 15 out of 30 (50%) respectively, P = 0.009].
There were no differences in mean white blood cells, hemoglobin, and platelets between the two groups at any time with only four patients dropping out due to anemia or side effect of medications.
Alanine aminotransferase was lower in both treatment groups compared to baseline with no difference between the groups.
Peginterferon α-2a and ribavirin are superior to
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ghamidi, Said Muhammad& al-Aulaqi, Nasir& al-Amudi, Abd Allah& al-Ghamidi, Aminah& Zagnun, Abbas& Bin Sadiq, Bakr. 2017. Superiority of peginterferon α-2a and ribavirin combination over peginterferon α-2a monotherapy in the management of hemodialysis patients with chronic hepatitis C virus infection. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 4, pp.799-805.
https://search.emarefa.net/detail/BIM-776139
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Ghamidi, Said Muhammad…[et al.]. Superiority of peginterferon α-2a and ribavirin combination over peginterferon α-2a monotherapy in the management of hemodialysis patients with chronic hepatitis C virus infection. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 4 (Jul. / Aug. 2017), pp.799-805.
https://search.emarefa.net/detail/BIM-776139
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ghamidi, Said Muhammad& al-Aulaqi, Nasir& al-Amudi, Abd Allah& al-Ghamidi, Aminah& Zagnun, Abbas& Bin Sadiq, Bakr. Superiority of peginterferon α-2a and ribavirin combination over peginterferon α-2a monotherapy in the management of hemodialysis patients with chronic hepatitis C virus infection. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 4, pp.799-805.
https://search.emarefa.net/detail/BIM-776139
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 804-805
رقم السجل
BIM-776139
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر